システム癌新次元

がんシステムの新次元俯瞰と攻略

文部科学省科学研究費補助金 新学術領域研究 (研究領域提案型)(複合領域:4701)
研究期間:平成27年度~31年度

 

研究成果

更新中

研究代表者&分担者の表記

  • 代表者:下線付き太線
  • 分担者:下線付き

論文 2017

  1. Shiokawa D, Sato A, Ohata H, Mutoh M, Sekine S, Kato M, Shibata T, Nakagama H, Okamoto K. The Induction of Selected Wnt Target Genes by Tcf1 Mediates Generation of Tumorigenic Colon Stem Cells. Cell Rep. 19, 981-994. doi: 10.1016/j.celrep.2017.04.017. (2017)
  2. Ishiguro T, Ohata H, Sato A, Yamawaki K, Enomoto T, Okamoto K. Tumor-derived spheroids: Relevance to cancer stem cells and clinical applications. Cancer Sci. doi: 10.1111/cas.13155. (2017)
  3. Shigemizu D, Iwase T, Yoshimoto M, Suzuki Y, Miya F, Boroevich KA, Katagiri T, Zembutsu H, Tsunoda T. The prediction models for postoperative overall survival and disease-free survival in patients with breast cancer. Cancer Med. in press
  4. Yoshimaru T, Aihara K, Komatsu M, Matsushita Y, Okazaki Y, Toyokuni S, Honda J, Sasa M, Miyoshi Y, Otaka A, Katagiri T. Stapled BIG3 helical peptide ERAP extends potent antitumor activity for breast cancer therapeutics. Sci Rep. in press
  5. Yoshimaru T, Ono M, Bando Y, Chen YA, Mizuguchi K, Shima H, Komatsu M, Imoto I, Izumi K, Honda J, Miyoshi Y, Sasa M, Katagiri T. A-kinase anchoring protein BIG3 coordinates oestrogen signaling in breast cancer cells. Nat Commun. 2017 in press
  6. Iwamoto T, Katagiri T, Niikura N, Miyoshi Y, Kochi M, Nogami T, Shien T, Motoki T, Taira N, Omori M, Tokuda Y, Fujiwara T, Doihara H, Gyorffy B, Matsuoka J. Immunohistochemical Ki67 after short-term hormone therapy identifies low-risk breast cancers as reliably as genomic markers. Oncotarget. 2017 Apr 18;8(16):26122-26128
  7. Shikata Y, Yoshimaru T, Komatsu M, Katoh H, Sato R, Kanagaki S, Okazaki Y, Toyokuni S, Tashiro E, shikawa S, Katagiri T, Imoto M. Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor. Cancer Sci. 2017 Jan 25. doi: 10.1111/cas.13175
  8. Uno Y, Takata R, Kito G, Yamazaki Y, Nakagawa K , Nakamura Y, Kamataki T, Katagiri T. Sex- and age-dependent gene expression in human liver: an implication for drug-metabolizing enzymes. Drug Metabolism and Pharmacokinetics. 2017 Feb;32(1):100-107
  9. Obara W, Karashima T, Takeda K, Kato R, Kato Y, Kanehira M, Takata R, Inoue K, Katagiri T, Shuin T, Nakamura Y, Fujioka T. Effective induction of cytotoxic T cells recognizing an epitope peptide derived from Hypoxia-Inducible Protein 2 (HIG2) in patients with metastatic renal cell carcinoma. Cancer Immunol Immunother., 2017 Jan;66(1):17-24.
  10. Liu Z, Yanagisawa K, Griesing S, Iwai M, Kano K, Hotta N, Kajino T, Suzuki M, Takahashi T. TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas. Oncogene 2017 Feb 13. doi: 10.1038/onc.2016.524. [Epub ahead of print]
  11. Griesing, S, Kajino T, Tai MC, Liu Z, Nakatochi M, Shimada Y, Suzuki M, Takahashi T. TTF-1-regulated miR-532-5p targets KRAS and MKL2 oncogenes and induces apoptosis in lung adenocarcinoma cells. Cancer Sci. 2017 (in press)
  12. Emura T, Nakatochi M, Matsui S, Michimae H, Rondeau V. Personalized dynamic prediction of death according to tumour progression and high-dimensional genetic factors: Meta-analysis with a joint model. Stat Methods Med Res. 2017 Jan 1:962280216688032. doi: 10.1177/0962280216688032. [Epub ahead of print]
  13. Suzawa K, Yamamoto H, Ohashi K, Hashida S, Tomida S, Kubo T, Maki Y, Soh J, Tsukuda K, Kiura K, Miyoshi S, Toyooka S. Optimal method for quantitative detection of plasma EGFR T790M mutation using droplet digital PCR system. Oncol Rep. 2017 May;37(5):3100-3106. doi: 10.3892/or.2017.5567. Epub 2017 Apr 11. PubMed PMID: 28405680.
  14. Takeda T, Yamamoto H, Kanzaki H, Suzawa K, Yoshioka T, Tomida S, Cui X, Murali R, Namba K, Sato H, Torigoe H, Watanabe M, Shien K, Soh J, Asano H, Tsukuda K, Kitamura Y, Miyoshi S, Sendo T, Toyooka S. Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer. PLoS One. 2017 Feb 3;12(2):e0171356. doi: 10.1371/journal.pone.0171356. eCollection 2017. Erratum in: PLoS One. 2017 Mar 16;12 (3):e0174493. PubMed PMID: 28158234; PubMed Central PMCID: PMC5291431.
  15. Sato H, Shien K, Tomida S, Okayasu K, Suzawa K, Hashida S, Torigoe H, Watanabe M, Yamamoto H, Soh J, Asano H, Tsukuda K, Miyoshi S, Toyooka S. Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features. Sci Rep. 2017 Jan 13;7:40847. doi: 10.1038/srep40847. PubMed PMID: 28084458; PubMed Central PMCID: PMC5233972.
  16. Suzawa K, Shien K, Peng H, Sakaguchi M, Watanabe M, Hashida S, Maki Y, Yamamoto H, Tomida S, Soh J, Asano H, Tsukuda K, Nasu Y, Kumon H, Miyoshi S, Toyooka S. Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies. Anticancer Res. 2017 Jan;37(1):301-307. PubMed PMID: 28011506.
  17. Kato D, Osakabe A, Arimura Y, Mizukami Y, Horikoshi N, Saikusa K, Akashi S, Nishimura Y, Park SY, Nogami J, Maehara K, Ohkawa Y, Matsumoto A, Kono H, Inoue R, Sugiyama M, Kurumizaka H. Crystal structure of the overlapping dinucleosome composed of hexasome and octasome. Science. 2017 Apr 14;356(6334):205-208.
  18. Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H, Yamagata K. Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis. Cell Rep. 2017 Jan 17;18(3):593-600.
  19. Okamoto A, Sumi C, Tanaka H, Kusunoki M, Iwai T, Nishi K, Matsuo Y, Harada H, Takenaga K, Bono H, Hirota K. HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death. Sci Rep. in press.
  20. Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo BN, Kita S, O'Donnell E, Osawa T, Takahashi H, Takano K, Dohmoto M, Sugimori M, Usui I, Watanabe Y, Hatakeyama N, Iwamoto T, Komuro I, Takatsu K, Tobe K, Niida S, Matsuda N, Shibuya M, Sasahara M A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS. Scientific Reports 2017 In press.
  21. Kanki Y, Nakaki R, Shimamura T, Matsunaga T, Yamamizu K, Katayama S, Suehiro JI, Osawa T, Aburatani H, Kodama T, Wada Y, Yamashita JK, Minami T. Dynamically and epigenetically coordinated GATA/ETS/SOX transcription factor expression is indispensable for endothelial cell differentiation. Nucleic Acids Res. 2017 May 5;45(8):4344-4358. doi: 10.1093/nar/gkx159. PMID: 28334937
  22. Kondo A, Yamamoto S, Nakaki R, Shimamura T, Hamakubo T, Sakai J, Kodama T, Yoshida T, Aburatani H, Osawa T. Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression. Cell Reports 2017 Feb 28;18(9):2228-2242. doi: 10.1016/j.celrep.2017.02.006. PMID: 28249167
  23. Matsui Y, Niida A, Uchi R, Mimori K, Miyano S, Shimamura T. phyC: Clustering cancer evolutionary trees. PLoS Comput Biol. 2017 May 1;13(5):e1005509. doi: 10.1371/journal.pcbi.1005509. [Epub ahead of print] PubMed PMID: 28459850.
  24. Ishida K, Ito C, Ohmori Y, Kume K, Sato KA, Koizumi Y, Konta A, Iwaya T, Nukatsuka M, Kobunai T, Takechi T, *Nishizuka SS. Inhibition of PI3K suppresses propagation of drug-tolerant cancer cell subpopulations enriched by 5-fluorouracil. Sci Rep. in press.
  25. Ito C, *Nishizuka SS, Ishida K, Uesugi N, Sugai T, Tamura G, Koeda K, Sasaki A. Analysis of PIK3CA mutations and PI3K pathway proteins in advanced gastric cancer. J Surg Res. 2017 May 15; 212, 195–204.
  26. Akiyama Y, Iwaya T, Endo F, Shioi Y, Chiba T, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Kimura Y, Sasaki A. Stability of cervical esophagogastrostomy via hand-sewn anastomosis after esophagectomy for esophageal cancer. Dis Esophagus. 2017 May 1;30(5):1-7.
  27. Masuda M, *Yamada T. The emergence of TNIK as a therapeutic target for colorectal cancer. Expert Opin Ther Targets. 2017 Apr;21(4):353-355.
  28. Yamada T, Masuda M. The emergence of TNIK inhibitors in cancer therapeutics. Cancer Sci. 2017, Feb 16. doi: 10.1111/cas.13203. In press.
  29. Hirata Y, Kobayashi T, Nishiumi S, Yamanaka K, Nakagawa T, Fujigaki S, Iemoto T, Kobayashi M, Okusaka T, Nakamori S, Shimahara M, Ueno T, Tsuchida A, Sata N, Ioka T, Yasunami Y, Kosuge T, Kaneda T, Kato T, Yagihara K, Fujita S, Yamada T, Honda K, Azuma T, *Yoshida M. Identification of highly sensitive biomarkers that can aid the early detection of pancreatic cancer using GC/MS/MS-based targeted metabolomics. Clinica Chimica Acta. 2017 Feb 16;468:98-104.
  30. Iwaya T, Sawada G, Amano S, Kume K, Ito C, Endo F, Konosu M, Shioi Y, Akiyama Y, Takahara T, Otsuka K, Nitta H, Koeda K, Mizuno M, Nishizuka S, Sasaki A, Mimori K. Downregulation of ST6GALNAC1 is associated with esophageal squamous cell carcinoma development. Int J Oncol. 2017 Feb;50(2):441-447
  31. Konosu M, *Iwaya T, Kimura Y, Akiyama Y, Shioi Y, Endo F, Nitta H, Otsuka K, Koeda K, Sasaki A. Peripheral vein infusions of amino acids facilitate recovery after esophagectomy for esophageal cancer: Retrospective cohort analysis. Ann Med Surg (Lond). 2017 Jan 16;14:29-35.
  32. Ito Y, Maeda D, Yoshida M, Yoshida A, Kudo-Asabe Y, Nanjyo H, Izumi C, Yamamoto F, Inoue M, Shibata H, Katoh H, Ishikawa S, Nakamura H, Totoki Y, Shibata T, Yachida S, Goto A. Cardiac intimal sarcoma with PDGFRβ mutation and co-amplification of PDGFRα and MDM2: an autopsy case analyzed by whole-exome sequencing. Virchows Arch. 2017 May 4. doi: 10.1007/s00428-017-2135-x. [Epub ahead of print]
  33. Ogura K, HosodA F, NakamurA H, HamA N, Totoki Y, YoshidA A, Ohashi S, Rokutan H, Takai E, Yachida S, Kawai A, Tanaka S, Shibata T. Highly recurrent H3F3A mutation with additional epigenetic regulator alterations in giant cell tumor of bone. Genes Chromosomes Cancer. 2017 in press
  34. Hiramoto H, Muramatsu T, Ichikawa D, Tanimoto K, Yasukawa S, Otsuji E, *Inazawa J: miR-509-5p and miR-1243 increase the sensitivity to gemcitabine by inhibiting epithelial-mesenchymal transition in pancreatic cancer. Scientific Reports (in press)
  35. Nagata H, Kozaki K, Muramatsu T, Hiramoto H, Tanimoto K, Fujiwara N, Imoto S, Ichikawa D, Otsuji E, Miyano S, Kawano T, *Inazawa J: Genome-wide screening of DNA methylation associated with lymph node metastasis in esophageal squamous cell carcinoma. Oncotarget (in press)
  36. Okuda M, Inoue J, Fujiwara N, Kawano T, *Inazawa J: Subcloning and characterization of highly metastatic cells derived from human esophageal squamous cell carcinoma KYSE150 cells by in vivo selection. Oncotarget (in press)
  37. Takahashi H, *Inoue J, Sakaguchi K, Takagi M, Mizutani S, *Inazawa J. Autophagy is required for cell survival under L-asparaginase–induced metabolic stress in acute lymphoblastic leukemia cells. Oncogene (in press), *corresponding authors
  38. Takaoka M, Ito S, *Miki Y, Nakanishi A. FKBP51 regulates cell motility and invasion via RhoA signaling. Cancer Sci. 2017;108(3):380-389.
  39. Hoshi R, Watanabe Y, Ishizuka Y, Hirano T, Nagasaki-Maeoka E, Yoshizawa S, Uekusa S, Kawashima H, Ohashi K, Sugito K, Fukuda N, Nagase H, Soma M. Toshinori Ozaki5, Tsugumichi Koshinaga1 and Kyoko Fujiwara. Depletion of TFAP2E attenuates adriamycin-mediated apoptosis in human neuroblastoma cells. ONCOLOGY REPORTS 37: 2459-2464, 2017
  40. Noguchi R, Yamaguchi K, Ikenoue T, Terakado Y, Ohta Y, Yamashita N, Kainuma O, Yokoi S, Maru Y, Nagase H, Furukawa Y. Genetic alterations in Japanese extrahepatic biliary tract cancer. Oncology Letters in press
  41. Seow WJ, Matsuo K, Hsiung CA, Shiraishi K, Song M, Kim HN, Wong MP, Hong YC, Hosgood HD 3rd, Wang Z, Chang IS, Wang JC, Chatterjee N, Tucker M, Wei H, Mitsudomi T, Zheng W, Kim JH, Zhou B, Caporaso NE, Albanes D, Shin MH, Chung LP, An SJ, Wang P, Zheng H, Yatabe Y, Zhang XC, Kim YT, Shu XO, Kim YC, Bassig BA, Chang J, Ho JC, Ji BT, Kubo M, Daigo Y, Ito H, Momozawa Y, Ashikawa K, Kamatani Y, Honda T, Sakamoto H, Kunitoh H, Tsuta K, Watanabe SI, Nokihara H, Miyagi Y, Nakayama H, Matsumoto S, Tsuboi M, Goto K, Yin Z, Shi J, Takahashi A, Goto A, Minamiya Y, Shimizu K, Tanaka K, Wu T, Wei F, Wong JY, Matsuda F, Su J, Kim YH, Oh IJ, Song F, Lee VH, Su WC, Chen YM, Chang GC, Chen KY, Huang MS, Yang PC, Lin HC, Xiang YB, Seow A, Park JY, Kweon SS, Chen CJ, Li H, Gao YT, Wu C, Qian B, Lu D, Liu J, Jeon HS, Hsiao CF, Sung JS, Tsai YH, Jung YJ, Guo H, Hu Z, Wang WC, Chung CC, Lawrence C, Burdett L, Yeager M, Jacobs KB, Hutchinson A, Berndt SI, He X, Wu W, Wang J, Li Y, Choi JE, Park KH, Sung SW, Liu L, Kang CH, Hu L, Chen CH, Yang TY, Xu J, Guan P, Tan W, Wang CL, Sihoe AD, Chen Y, Choi YY, Hung JY, Kim JS, Yoon HI, Cai Q, Lin CC, Park IK, Xu P, Dong J, Kim C, He Q, Perng RP, Chen CY, Vermeulen R, Wu J, Lim WY, Chen KC, Chan JK, Chu M, Li YJ, Li J, Chen H, Yu CJ, Jin L, Lo YL, Chen YH, Fraumeni JF Jr, Liu J, Yamaji T, Yang Y, Hicks B, Wyatt K, Li SA, Dai J, Ma H, Jin G, Song B, Wang Z, Cheng S, Li X, Ren Y, Cui P, Iwasaki M, Shimazu T, Tsugane S, Zhu J, Jiang G, Fei K, Wu G, Chien LH, Chen HL, Su YC, Tsai FY, Chen YS, Yu J, Stevens VL, Laird-Offringa IA, Marconett CN, Lin D, Chen K, Wu YL, Landi MT, Shen H, Rothman N, Kohno T, Chanock SJ, Lan Q. Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Hum Mol Genet. (査読あり) 2017 Jan 15;26(2):454-465 .
  42. Ishigaki K, *Kochi Y, …, Okada Y, …, Kamatani Y, et al. “Polygenic burdens on cell-specific pathways underlie the risk of rheumatoid arthritis” Nat Genet 査読有, in press (2017).
  43. van Rooij FJ, …, Okada Y, …, *Ganesh SK. “Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis” Am J Hum Genet査読有, 100, 51-63 (2017).
  44. Nakayama A, …, Okada Y, …, Kamatani Y, …, *Matsuo H. “GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes” Ann Rheum Dis査読有, 76, 869-877 (2017).
  45. J. Lin, S. Chung, K. Ueda, K. Matsuda, Y. Nakamura, *J.H. Park, GALNT6 Stabilizes GRP78 Protein by O-glycosylation and Enhances its Activity to Suppress Apoptosis Under Stress Condition, Neoplasia, 19 (2017) 43-53.
  46. J. Mori, C. Tanikawa, N. Ohnishi, Y. Funauchi, O. Toyoshima, K. Ueda,* K. Matsuda, EPSIN 3, a novel p53 target, regulates the apoptotic pathway and gastric carcinogenesis, Neoplasia, 19 (2017) 185-195.
  47. T. Miyamoto, P. H. Y. Lo, N. Saichi, K. Ueda, M. Hirata, C. Tanikawa, *K. Matsuda Argininosuccinate synthase 1 is an intrinsic Akt repressor transactivated by p53. Science Advances DOI: 10.1126/sciadv.1603204.
  48. C. Tanikawa, Y.Z. Zhang, R. Yamamoto, Y. Tsuda, M. Tanaka, Y. Funauchi, J. Mori, S. Imoto, R. Yamaguchi, Y. Nakamura, S. Miyano, H. Nakagawa, *K. Matsuda. The Transcriptional Landscape of p53 Signalling Pathway. Ebiomedicine doi.org/10.1016/j.ebiom.2017.05.017
  49. 武藤香織、ゲノム医療を目指す研究における倫理的配慮、腎臓内科・泌尿器科、査読なし、5(1):1-4、2017年
  50. 中田はる佳、井上悠輔、2016年末に成立した米国「21世紀治療法」、薬理と治療、査読なし、45(S1):S45-S48、2017年

論文 2016

  1. Nakamura T, Katagiri T, Sato S, Kushibiki T, Tsuchikawa T, Hirano S, Nakamura Y. Overexpression of C16orf74 is involved in aggressive pancreatic cancers. Oncotarget. 2016. Jul 28
  2. Park JH, Jang M, Tarhan YM, Katagiri T, Sasa M, Miyoshi Y, Kalari KR, Suman VJ, Weinshilboum R, Wang L, Boughey JC, Goetz MP, Nakamura Y. Clonal expansion of anti-tumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy. Int J Oncol. 2016 Aug;49(2):471-8
  3. Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, Hotta N, Shimada Y, Isomura H, Suzuki M, Fujimoto T, Takahashi T. ROR1 sustains caveolae and survival signaling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016 Jan 4;7:10060. doi: 10.1038/ncomms10060.
  4. Suzuki, M, Cao K, Kato S, Komizu Y, Mizutani N, Tanaka K, Arima C, Chee TM, Yanagisawa K, Tagawa N, Shiraishi T, Usami N, Taniguchi T, Fukui T, Yokoi K, Wakahara K, Hasegawa Y, Mizutani Y, Igarashi Y, Inokuchi J, Iwaki S, Fujii S, Satou A, Matsumoto Y, Ueoka R, Tamiya-Koizumi K, Murate T, Nakamura M, Kyogashima M, Takahashi T. Targeting CERS6-dependent metastasis-prone phenotype in lung cancer cells. J Clin Invest. 2016 Jan;126(1):254-65. doi: 10.1172/JCI79775. Epub 2015 Dec 7.
  5. Kakiuchi T, Takahara T, Kasugai Y, Arita K, Yoshida N, Karube K, Suguro M, Matsuo K, Nakanishi H, Kiyono T, Nakamura S, Osada H, Sekido Y, Seto M, Tsuzuki S. Modeling mesothelioma utilizing human mesothelial cells reveals involvement of phospholipase-C beta 4 in YAP-active mesothelioma cell proliferation. Carcinogenesis 2016 Aug; 37 (11): 1098-1109. doi: 10.1093/carcin/bgw084
  6. Tanaka K, Osada H, Murakami-Tonami Y, Horio Y, Hida T, Sekido Y. Statin suppresses Hippo pathway-inactivated malignant mesothelioma cells and blocks the YAP/CD44 growth stimulatory axis. Cancer Lett. 2017 Jan 28;385:215-224. doi: 10.1016/j.canlet.2016.10.020.
  7. Ida L, Yamaguchi, T, Yanagisawa K, Kajino T, Shimada Y, Suzuki M, Takahashi T. Receptor tyrosine kinase-like orphan receptor 1, a target of NKX2-1/TTF-1 lineage-survival oncogene, inhibits apoptosis signal-regulating kinase 1-mediated pro-apoptotic signaling in lung adenocarcinoma. Cancer Sci. 2016 Feb;107(2):155-61. doi: 10.1111/cas.12858. Epub 2016 Feb 8.
  8. Tai MC, Yanagisawa K, Nakatochi M, Hotta N, Hosono Y, Kawaguchi K, Naito M, Taniguchi H, Wakai K, Yokoi K, Takahashi T. Blood-borne miRNA profile-based diagnostic classifier for lung adenocarcinoma. Sci Rep. 2016 Aug 10;6:31389. doi: 10.1038/srep31389.
  9. Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, Hashida S,Miyata-Takata T, Watanabe M, Suzawa K, Soh J, Youyi C, Sato H, Namba K, Torigoe H, Tsukuda K, Yoshino T, Miyoshi S, Toyooka S. Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway. Sci Rep. 2016 Dec 23;6:39557. doi: 10.1038/srep39557. PubMed PMID: 28008968; PubMed Central PMCID: PMC5180104.
  10. Saho S, Satoh H, Kondo E, Inoue Y, Yamauchi A, Murata H, Kinoshita R, Yamamoto KI, Futami J, Putranto EW, Ruma IM, Sumardika IW, Youyi C, Suzawa K, Yamamoto H, Soh J, Tomida S, Sakaguchi Y, Saito K, Iioka H, Huh NH, Toyooka S, Sakaguchi M. Active Secretion of Dimerized S100A11 Induced by the Peroxisome in Mesothelioma Cells. Cancer Microenviron. 2016 Dec;9(2-3):93-105. doi: 10.1007/s12307-016-0185-2. Epub 2016 Jun 22. PubMed PMID: 27334300; PubMed Central PMCID: PMC5264658.
  11. Kitai H, Ebi H, Tomida S, Floros KV, Kotani H, Adachi Y, Oizumi S, Nishimura M, Faber AC, Yano S. Epithelial-to-Mesenchymal Transition Defines Feedback Activation of Receptor Tyrosine Kinase Signaling Induced by MEK Inhibition in KRAS-Mutant Lung Cancer. Cancer Discov. 2016 Jul;6(7):754-69. doi: 10.1158/2159-8290.CD-15-1377. Epub 2016 May 6. PubMed PMID: 27154822; PubMed Central PMCID: PMC4957999.
  12. Kuniyoshi Y†, Maehara K†, Iwasaki T, Hayashi M, Semba Y, Fujita M, Sato Y, Kimura H, Harada A, Ohkawa Y. Identification of Immunoglobulin Gene Sequences from a Small Read Number of mRNA-Seq Using Hybridomas. PLoS One. 2016 Oct 27;11(10):e0165473.
  13. Kujirai T, Horikoshi N, Sato K, Maehara K, Machida S, Osakabe A, Kimura H, Ohkawa Y, Kurumizaka H. Structure and function of human histone H3.Y nucleosome. Nucleic Acids Res. 2016 Jul 27;44(13):6127-41.
  14. Kaimori JY†, Maehara K†, Hayashi-Takanaka Y, Harada A, Fukuda M, Yamamoto S, Ichimaru N, Umehara T, Yokoyama S, Matsuda R, Ikura T, Nagao K, Obuse C, Nozaki N, Takahara S, Takao T, Ohkawa Y, Kimura H, Isaka Y. Histone H4 lysine 20 acetylation is associated with gene repression in human cells. Sci Rep. 2016 Apr 11;6:24318.
  15. Kobayashi W, Takaku M, Machida S, Tachiwana H, Maehara K, Ohkawa Y, Kurumizaka H. Chromatin architecture may dictate the target site for DMC1, but not for RAD51, during homologous pairing. Sci Rep. 2016 Apr 7;6:24228.
  16. Sowa T, Menju T, Chen-Yoshikawa TF, Takahashi K, Nishikawa S, Nakanishi T, Shikuma K, Motoyama H, Hijiya K, Aoyama A, Sato T, Sonobe M, Harada H, Date H. Hypoxia-inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression. Cancer Med. 2017 Jan;6(1):288-297. doi: 10.1002/cam4.991. Epub 2016 Dec 28. PMID: 28028936
  17. Harada H. Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance. J Radiat Res. 2016 Aug;57 Suppl 1:i99-i105. doi: 10.1093/jrr/rrw012. PMID: 26983985
  18. Yeom CJ, Zeng L, Goto Y, Morinibu A, Zhu Y, Shinomiya K, Kobayashi M, Itasaka S, Yoshimura M, Hur CG, Kakeya H, Hammond EM, Hiraoka M, *Harada H. LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis. Oncotarget. 2016 Oct 4;7(40):65837-65848. doi: 10.18632/oncotarget.11670. PMID: 27589564
  19. Olcina MM, Leszczynska KB, Senra JM, Isa NF, Harada H, Hammond EM. H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK. Oncogene. 2016 Feb 11;35(6):793-9. doi: 10.1038/onc.2015.134. PMID: 25961932
  20. Daijo H, Hoshino Y, Kai S, Suzuki K, Nishi K, Matsuo Y, Harada H, Hirota K. Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner. Sci Rep. 2016 Sep 29;6:34424. doi: 10.1038/srep34424. PMID: 27680676
  21. Yamaguchi R, Harada H, Hirota K. VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway. Tumour Biol. 2016 Oct;37(10):13295-13306. Epub 2016 Jul 26. PMID: 27460078
  22. Gaowa A, Horibe T, Kohno M, Harada H, Hiraoka M, Kawakami K. Potent anti-tumor effects of EGFR-targeted hybrid peptide on mice bearing liver metastases. Clin Exp Metastasis. 2016 Jan;33(1):87-95. PMID: 26467564
  23. Koyasu S, Tsuji Y, Harada H, Nakamoto Y, Nobashi T, Kimura H, Sano K, Koizumi K, Hamaji M, Togashi K. Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and (18)F Misonidazole PET in Murine Tumor Models. Radiology. 2016 Mar;278(3):734-41. doi: 10.1148/radiol.2015150416. PMID: 26393963
  24. Matsui Y, Mizuta M, Ito S, Miyano S, Shimamura T. D3M: detection of differential distributions of methylation levels. Bioinformatics. 2016 Aug 1;32(15):2248-55. doi: 10.1093/bioinformatics/btw138. Epub 2016 Mar 11. PubMed PMID: 27153581
  25. Yokobori T, Suzuki S, Miyazaki T, Sohda M, Sakai M, Tanaka N, Ozawa D, Hara K, Honjo H, Altan B, Fukuchi M, Ishii H, Iwatsuki M, Sugimachi K, Sudo T, Iwaya T, Nishida N, Mimori K, Kuwano H, Mori M. Intestinal epithelial culture under an air-liquid interface: a tool for studying human and mouse esophagi. Dis Esophagus. 2016 Oct;29(7):843-847.
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  28. Yoneyama T, *Ohtsuki S, Honda K, Kobayashi M, Iwasaki M, Uchida Y, Okusaka T, Nakamori S, Shimahara M, Ueno T, Tsuchida A, Sata N, Ioka T, Yasunami Y, Kosuge T, Kaneda T, Kato T, Yagihara K, Fujita S, Huang W, Yamada T, Tachikawa M, Terasaki T. Identification of IGFBP2 and IGFBP3 As Compensatory Biomarkers for CA19-9 in Early-Stage Pancreatic Cancer Using a Combination of Antibody-Based and LC-MS/MS-Based Proteomics. PLoS One. 2016 Aug 31;11(8):e0161009
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  30. Miura N, Kamita M, Kakuya T, Fujiwara Y, Tsuta K, Shiraishi H, Takeshita F, Ochiya T, Shoji H, Huang W, Ohe Y, Yamada T, *Honda K. Efficacy of adjuvant chemotherapy for non-small cell lung cancer assessed by metastatic potential associated with ACTN4. Oncotarget. 2016 May 31;7(22):33165-78.
  31. Kume K, Ikeda M, Miura S, Ito K, Sato KA, Ohmori Y, Endo F, Katagiri H, Ishida K, Ito C, Iwaya T, *Nishizuka SS. α-Amanitin Restrains Cancer Relapse from Drug-Tolerant Cell Subpopulations via TAF15. Sci Rep. 2016 May 16;6:25895.
  32. Sawada G, Niida A, Uchi R, Hirata H, Shimamura T, Suzuki Y, Shiraishi Y, Chiba K, Imoto S, Takahashi Y, Iwaya T, Sudo T, Hayashi T, Takai H, Kawasaki Y, Matsukawa T, Eguchi H, Sugimachi K, Tanaka F, Suzuki H, Yamamoto K, Ishii H, Shimizu M, Yamazaki H, Yamazaki M, Tachimori Y, Kajiyama Y, Natsugoe S, Fujita H, Mafune K, Tanaka Y, Kelsell DP, Scott CA, Tsuji S, Yachida S, Shibata T, Sugano S, Doki Y, Akiyama T, Aburatani H, Ogawa S, Miyano S, Mori M, *Mimori K. Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. Gastroenterology. 2016 May;150(5):1171-82
  33. Sawa M, Masuda M, *Yamada T. Targeting the Wnt signaling pathway in colorectal cancer. Expert Opin Ther Targets. 2016 Apr;20(4):419-29.
  34. Yamamoto KN, Yachida S, Nakamura A, Niida A, Oshima M, De S, Rosati LM, Herman JM, Iacobuzio-Donahue CA, Haeno H. Personalized management of pancreatic ductal adenocarcinoma patients through computational modeling. Cancer Res. 2017 Apr 5. pii: canres.1208.2016. doi: 10.1158/0008-5472.CAN-16-1208. [Epub ahead of print]
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  37. Yachida S, Wood LD, Suzuki M, Takai E, Totoki Y, Kato M, Luchini C, Arai Y, Nakamura H, Hama N, Elzawahry A, Hosoda F, Shirota T, Morimoto N, Hori K, Funazaki J, Tanaka H, Morizane C, Okusaka T, Nara S, Shimada K, Hiraoka N, Taniguchi H, Higuchi R, Oshima M, Okano K, Hirono S, Mizuma M, Arihiro K, Yamamoto M, Unno M, Yamaue H, Weiss MJ, Wolfgang CL, Furukawa T, Nakagama H, Vogelstein B, Kiyono T, Hruban RH, Shibata T. Genomic Sequencing Identifies ELF3 as a Driver of Ampullary Carcinoma. Cancer Cell. 2016 Feb 8;29(2):229-40. doi: 10.1016/j.ccell.2015.12.012. Epub 2016 Jan 21.
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  40. Shiraishi K, Okada Y, Takahashi A, Kamatani Y, Momozawa Y, Ashikawa K, Kunitoh H, Matsumoto S, Takano A, Shimizu K, Goto A, Tsuta K, Watanabe S, Ohe Y, Watanabe Y, Goto Y, Nokihara H, Furuta K, Yoshida A, Goto K, Hishida T, Tsuboi M, Tsuchihara K, Miyagi Y, Nakayama H, Yokose T, Tanaka K, Nagashima T, Ohtaki Y, Maeda D, Imai K, Minamiya Y, Sakamoto H, Saito A, Shimada Y, Sunami K, Saito M, Inazawa J, Nakamura Y, Yoshida T, Yokota J, Matsuda F, Matsuo K, Daigo Y, Kubo M, Kohno T: Association of variations in HLA class II and other loci with susceptibility to EGFR-mutated lung adenocarcinoma. Nat Commun. 7:12451. 2016
  41. Nuylan M, Kawano T, Inazawa J, Inoue J: Down-regulation of LAPTM5 in human cancer cells. Oncotarget. 7:28320-8. 2016
  42. Muramatsu T, Kozaki K, Imoto S, Ymaguchi R, Tsuda H, Kawano T, Fujiwara N, Morishita M, Miyano S, *Inazawa J: The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma. Oncogene 35:5304-5316. 2016
  43. Okada Y, Muramatsu T, Suita N, Kanai M, Kawakami E, Iotchkova V, Soranzo N, Inazawa J, Tanaka T: Significant impact of miRNA-target gene networks on genetics of human complex traits. Sci Rep. 6:22223. 2016
  44. Morishita M, Muramatsu T, Suto Y, Hirai M, Konishi T, Hayashi S, Shigemizu D, Tsunoda T, Moriyama K, *Inazawa J: Chromothripsis-like chromosomal rearrangements induced by ionizing radiation using proton microbeam irradiation system. Oncotarget 7:10182-92. 2016
  45. Sudo G, Kagawa T, Kokubu Y, Inazawa J, Taga T: Increase in GFAP-positive astrocytes in histone demethylase GASC1/KDM4C/JMJD2C hypomorphic mutant mice. Genes Cells. 21:218-25 2016
  46. Malik S, Saito H, Takaoka M, *Miki Y, Nakanishi A. BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein. Cell Cycle. 2016; 15(16):2145-2156.
  47. Kobayashi K, Ito Y, Matsuura M, Fukada I, Horii R, Takahashi S, Akiyama F, Iwase T, Hozumi Y, Yasuda Y, *Hatake K. Impact of immunohistological subtypes on the long-term prognosis of patients with metastatic breast cancer. Surg Today. 2016;46(7):821-6.
  48. Maru Y, Tanaka N, Ohira M, Itami M, Hippo Y and Nagase H. Identification of Novel Mutations in Japanese Ovarian Clear Cell Carcinoma Patients using Optimized Targeted NGS for Clinical Diagnosis. Gynecologic Oncology 2016 Dec 8. pii: S0090-8258(16)31614-6. doi: 10.1016/j.ygyno.2016.11.045. [Epub ahead of print].
  49. Shinohara K, Yoda N, Takane K, Watanabe T, Fukuyo M, Fujiwara K, Kita K, Nagase H, Nemoto T, Kaneda A. Inhibition of DNA methylation at the MLH1 promoter region using pyrrole-imidazole polyamide. ACS Omega, 2016, 1 (6), 1164–1172
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  74. 丸祐一、遺伝子解析を伴う家族性腫瘍研究の倫理的諸問題、遺伝子医学MOOK別冊 最新遺伝医学研究と遺伝カウンセリングシリーズ1 遺伝性腫瘍・家族性腫瘍研究と遺伝カウンセリング、査読なし、321-324、2016年
  75. 丸祐一、倫理的な臨床研究を実施するための検討事項、肺癌、査読なし、56:969-971,2016年

論文 2015

  1. Ayada E, Niida A, Hasegawa T, Miyano S, Imoto S. Binary Contingency Table Method for Analyzing Gene Mutation in Cancer Genome. Lecture Notes in Computer Science. 9096:12-23, 2015.
  2. Chapman CG, Yamaguchi R, Tamura K, Weidner J, Imoto S, Kwon J, Marino SR, Miyano S, Nakamura Y, Kiyotani K. Characterization of T Cell Receptor Repertoire in Inflamed Tissues of Crohn’s Disease through Deep Sequencing. Inflammatory Bowel Diseases. In press
  3. Chiba K, Shiraishi Y, Nagata Y, Yoshida K, Imoto S, Ogawa S, Miyano S. Genomon ITDetector: a tool for somatic internal tandem duplication detection from cancer genome sequencing data. Bioinformatics. 31(1):116-118, 2015.
  4. Chikahara Y, Niida A, Yamaguchi R, Imoto S, Miyano S. Integrative Clustering of Cancer Genome Data using Infinite Relational Models. BioCoB 2015. 11-18, 2015.
  5. Eita MA, Shibuya T, Shoukry AA. Locating controlling regions of neural networks using constrained evolutionary computation. CEC 2015. 1581-1588, 2015.
  6. Fang H, Yamaguchi R, Liu X, Daigo Y, Yew PY, Tanikawa C, Matsuda K, Imoto S, Miyano S, Nakamura Y. Quantitative T cell repertoire analysis by deep cDNA sequencing of T cell receptor α and β chains using next-generation sequencing (NGS). Oncoimmunology. 3(12):e968467, 2015.
  7. Fujimoto A, Furuta M, Shiraishi Y, Gotoh K, Kawakami Y, Arihiro K, Nakamura T, Ueno M, Ariizumi S, Nguyen HH, Shigemizu D, Abe T, Boroevich KA, Nakano K, Sasaki A, Kitada R, Maejima K, Yamamoto Y, Tanaka H, Shibuya T, Shibata T, Ojima H, Shimada K, Hayami S, Shigekawa Y, Aikata H, Ohdan H, Marubashi S, Yamada T, Kubo M, Hirano S, Ishikawa O, Yamamoto M, Yamaue H, Chayama K, Miyano S, Tsunoda T, Nakagawa H. Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity. Nat Commun. 6:6120, 2015.
  8. Garg M, Nagata Y, Kanojia D, Mayakonda A, Yoshida K, Haridas Keloth S, Zang ZJ, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ding LW, Alpermann T, Sun QY, Lin DC, Chien W, Madan V, Liu LZ, Tan KT, Sampath A, Venkatesan S, Inokuchi K, Wakita S, Yamaguchi H, Chng WJ, Kham SK, Yeoh AE, Sanada M, Schiller J, Kreuzer KA, Kornblau SM, Kantarjian HM, Haferlach T, Lill M, Kuo MC, Shih LY, Blau IW, Blau O, Yang H, Ogawa S, Koeffler HP. Profiling of somatic mutations in acute myeloid leukemia with FLT3-ITD at diagnosis and relapse. Blood. 126(22):2491-2501, 2015.
  9. Hasegawa T, Mori T, Yamaguchi R, Shimamura T, Miyano S, Imoto S, Akutsu T. Genomic data assimilation using a higher moment filtering technique for restoration of gene regulatory networks. BMC Syst Biol. 9:14, 2015.
  10. Hasegawa T, Niida A, Mori T, Shimamura T, Yamaguchi R, Miyano S, Akutsu T, Imoto S. A Likelihood-free Filtering Method via Approximate Bayesian Computation in Evaluating Biological Simulation Models. Computational Statistics & Data Analysis. 94:63-74, 2016.
  11. Hira A, Yoshida K, Sato K, Okuno Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Shimamoto A, Tahara H, Ito E, Kojima S, Kurumizaka H, Ogawa S, Takata M, Yabe H, Yabe M. Mutations in the gene encoding the E2 conjugating enzyme UBE2T cause Fanconi anemia. Am J Hum Genet. 96(6):1001-1007, 2015.
  12. Hoshino A, Nomura K, Hamashima T, Isobe T, Seki M, Hiwatari M, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Takita J, Kanegane H. Aggressive transformation of anaplastic large cell lymphoma with increased number of ALK-translocated chromosomes. Int J Hematol. 101(2):198-202, 2015.
  13. Huang D, Nagata Y, Grossmann V, Radivoyevitch T, Okuno Y, Nagae G, Hosono N, Schnittger S, Sanada M, Przychodzen B, Kon A, Polprasert C, Shen W, Clemente MJ, Phillips JG, Alpermann T, Yoshida K, Nadarajah N, Sekeres MA, Oakley K, Nguyen N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Miyano S, Haferlach C, Kern W, Haferlach T, Du Y, Ogawa S, Makishima H. BRCC3 mutations in myeloid neoplasms. Haematologica. 100(8):1051-1057, 2015.
  14. Ikenoue T, Yamaguchi K, Koumura M, Imoto S, Yamaguchi R, Shimizu E, Kasuya S, Shibuya T, Hatakeyama S, Miyano S, Furukawa Y. Attenuated familial adenomatous polyposis with desmoids caused by an APC mutation. Human Genome Variation. 2:15011, 2015.
  15. Inazawa J, Muramatsu T, Kozaki K, Imoto S, Yamaguchi R, Tsuda H, Kawano T, Fujiwara N, Morishita M, Miyano S. The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma. Oncogene. In press.
  16. Ito S, Shiraishi Y, Shimamura T, Chiba K, Miyano S. High performance computing of a fusion gene detection pipeline on the K computer. BIBM 2015. 1441-1447, 2015.
  17. Ito H, Shiwaku H, Yoshida C, Homma H, Luo H, Chen X, Fujita K, Musante L, Fischer U, Frints SG, Romano C, Ikeuchi Y, Shimamura T, Imoto S, Miyano S, Muramatsu SI, Kawauchi T, Hoshino M, Sudol M, Arumughan A, Wanker EE, Rich T, Schwartz C, Matsuzaki F, Bonni A, Kalscheuer VM, Okazawa H. In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells. Mol Psychiatry. 20(4):459-471, 2015.
  18. Iwakawa R, Kohno T, Totoki Y, Shibata T, Tsuchihara K, Mimaki S, Tsuta K, Narita Y, Nishikawa R, Noguchi M, Harris CC, Robles AI, Yamaguchi R, Imoto S, Miyano S, Totsuka H, Yoshida T, Yokota J. Expression and clinical significance of genes frequently mutated in small cell lung cancers defined by whole exome/RNA sequencing. Carcinogenesis. 36(6):616-621, 2015.
  19. Kanojia D, Nagata Y, Garg M, Lee DH, Sato A, Yoshida K, Sato Y, Sanada M, Mayakonda A, Bartenhagen C, Klein HU, Doan NB, Said JW, Mohith S, Gunasekar S, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Myklebost O, Yang H, Dugas M, Meza-Zepeda LA, Silberman AW, Forscher C, Tyner JW, Ogawa S, Koeffler HP. Genomic landscape of liposarcoma. Oncotarget. 6(40):42429-42444, 2015.
  20. Kataoka K, Nagata Y, Kitanaka A, Shiraishi Y, Shimamura T, Yasunaga J, Totoki Y, Chiba K, Sato-Otsubo A, Nagae G, Ishii R, Muto S, Kotani S, Watatani Y, Takeda J, Sanada M, Tanaka H, Suzuki H, Sato Y, Shiozawa Y, Yoshizato T, Yoshida K, Makishima H, Iwanaga M, Ma G, Nosaka K, Hishizawa M, Itonaga H, Imaizumi Y, Munakata W, Ogasawara H, Sato T, Sasai K, Muramoto K, Penova M, Kawaguchi T, Nakamura H, Hama N, Shide K, Kubuki Y, Hidaka T, Kameda T, Nakamaki T, Ishiyama K, Miyawaki S, Yoon SS, Tobinai K, Miyazaki Y, Takaori-Kondo A, Matsuda F, Takeuchi K, Nureki O, Aburatani H, Watanabe T, Shibata T, Matsuoka M, Miyano S, Shimoda K, Ogawa S. Integrated molecular analysis of adult T cell leukemia/lymphoma. Nat Genet. 47(11):1304-1315, 2015.
  21. Kato M, Seki M, Yoshida K, Sato Y, Oyama R, Arakawa Y, Kishimoto H, Taki T, Akiyama M, Shiraishi Y, Chiba K, Tanaka H, Mitsuiki N, Kajiwara M, Mizutani S, Sanada M, Miyano S, Ogawa S, Koh K, Takita J. Genomic analysis of clonal origin of Langerhans cell histiocytosis following acute lymphoblastic leukaemia. Br J Haematol. 2015 Nov 5. doi: 10.1111/bjh.13841. [Epub ahead of print]
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